|Home World:||Real World|
|Debut:||The End of the Beginning|
|Portrayer:||Christopher Anthony Muller|
Genome Soldiers are Liquid Snake's genetically modified henchmen.
After battling in close-quarters combat, Solid Snake easily kills one by snapping its neck. Bored with there current situation, Snake questions with Otacon about the Genome Soldiers' recent resurgence, having killed several already. Snake wonders why they are still after him, seeing as Liquid already had died. Otacon suggests they may be following his last commands. ("The End of the Beginning")
Genome Soldiers regularly continue appearing, though they aren't actually seen.
While meeting up with Otacon, Solid Snake mentions he killed two just on his way there. Picking up on their discussing from last time, Snake once again asks why they could be resuming their work. Otacon brings up his theory again, adding that they may be retaliating at the death of their leader, though Snake replies they wouldn't act on such terms. ("Act II Part 1")